It sounds like you both need to seek professional help. I can offer my opinion, but the issues you raised are very deep and serious, and they need to be dealt with immediately and carefully.

You say that you have tried everything to win your wife back, and it may seem hopeless,

He should stick with her not because they are family but because he loves her deeply.

but you need to persevere and wait for her. You are still married, so you are still one with her. You are family, and family should stick together no matter what.

It sounds as though your wife is dealing with insecurities, past hurts from her childhood, mistrust, and depression -- all at the same time. (And depression has a way of distorting relationships, especially her perception of your marriage.) It also sounds like she did not have much security growing up, so she really needs to perceive security in your relationship. She needs you now more than ever, even though she is pushing you away. More importantly, she needs to see your devotion to her demonstrated to feel secure in your relationship. You can demonstrate this by refusing to give up on your marriage, by doing things to help her or finding creative ways to show your love for her, by putting her first above work or any other relationship, and by spending time with her and being sensitive to her feelings even though you don't understand them. This will reassure her that you will be there for her no matter what. After all, commitment means nothing until it is tried and tested, then found to be lasting.

This may be the most difficult thing you will ever do, but you need to hang in there with her, and seek professional help along the way to get you through this most difficult time. This is where the commitment of marriage becomes so meaningful and beautiful -- when you choose to sacrifice your own desires and pride and remain completely devoted, even though you are getting nothing in return.

Do you belong to a church? Perhaps you could seek counsel with your pastor. Better yet, go to the "Great Physician" -- God Himself -- and ask him to heal your broken heart and your marriage. He alone is the one who can turn our lives around, if we give our lives to Him and ask Him to come into our heart. He loves you and your family more than you could ever know. Jesus said "I am the Way, the Truth, and the Life." He also said " I have come that they may have life and have it more abundantly." Turn to Him and allow Him to be your strength during this difficult time. You are in my prayers!